Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10766786 | 0.86 | RAB9A (0.56) | TDP1L3MBTL1SMN1; SMN2POLBAPEX1 | |
| SCHEMBL4985915 | 0.82 | HSD17B10 (0.50) | TDP1L3MBTL1SMN1; SMN2POLBAPEX1 | |
| SCHEMBL10768404 | 0.81 | POLB (0.46) | TDP1L3MBTL1SMN1; SMN2POLBAPEX1 | |
| SCHEMBL7383210 | 0.81 | ALDH1A1 (0.64) | L3MBTL1SMN1; SMN2POLBALDH1A1RAB9A | |
| SCHEMBL4983346 | 0.80 | HSD17B10 (0.53) | TDP1SMN1; SMN2POLBAPEX1HSD17B10 | |
| SCHEMBL3183400 | 0.80 | SMN1; SMN2 (0.55) | TDP1SMN1; SMN2POLBAPEX1HSD17B10 | |
| SCHEMBL9760318 | 0.80 | HSD17B10 (0.48) | TDP1L3MBTL1SMN1; SMN2POLBAPEX1 | |
| SCHEMBL7906481 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2POLBALDH1A1RAB9AMEN1 | |
| SCHEMBL7373567 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2POLBALDH1A1RAB9AMEN1 | |
| SCHEMBL10766778 | 0.79 | SMN1; SMN2 (0.46) | TDP1L3MBTL1SMN1; SMN2POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057332-A | Substituted 1,4-dihydropyrimidine-5-carboxylate compounds, their preparation and uses | ASTRA AKTIEBOLAG (SE) | 2000-05-02 | — | — | US | disclosed |