Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8137044 | 0.93 | ALDH1A1 (0.57) | ALDH1A1KDM4ELMNARECQLHTT | |
| SCHEMBL8141322 | 0.88 | ALDH1A1 (0.61) | ALDH1A1KDM4ELMNARECQLHTT | |
| SCHEMBL2438657 | 0.83 | ALDH1A1 (0.55) | ALDH1A1KDM4ELMNARECQLHTT | |
| SCHEMBL8137427 | 0.81 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNARECQLHTT | |
| SCHEMBL12291956 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNARECQLHTT | |
| SCHEMBL11639617 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNARECQLHTT | |
| SCHEMBL11075024 | 0.77 | L3MBTL1 (0.49) | ALDH1A1KDM4ELMNACYP1A2HTT | |
| SCHEMBL11486123 | 0.77 | ALDH1A1 (0.57) | ALDH1A1KDM4ELMNARECQLHTT | |
| SCHEMBL11083105 | 0.76 | KDM4E (0.60) | ALDH1A1KDM4ELMNARECQLHTT | |
| SCHEMBL10080871 | 0.76 | ALDH1A1 (0.55) | ALDH1A1KDM4ELMNARECQLHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784623-B1 | NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 2000-03-08 | — | — | EP | claimed |
| US-5712286-A | MODULATORS OF CYTOKINE SYNTHESIS, ANTIRHEUMATIC AGENTS | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-01-27 | — | — | US | claimed |
| EP-0784623-B1 | NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 2000-03-08 | — | — | EP | disclosed |
| US-5712286-A | MODULATORS OF CYTOKINE SYNTHESIS, ANTIRHEUMATIC AGENTS | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-01-27 | — | — | US | disclosed |