Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 8/20 | 0.45 |
| ▸ | MAOB | P27338 | 8/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8145110 | 0.87 | MAOA (0.62) | MAOAMAOB | |
| SCHEMBL8129843 | 0.86 | CYSLTR1 (0.53) | — | |
| SCHEMBL8140542 | 0.81 | MAOB (0.55) | MAOAMAOB | |
| SCHEMBL5848736 | 0.80 | MAOA (0.68) | MAOAMAOB | |
| SCHEMBL8140420 | 0.79 | PDE10A (0.49) | MAOAMAOB | |
| SCHEMBL8145824 | 0.77 | MAOB (0.63) | MAOAMAOB | |
| SCHEMBL8320614 | 0.74 | CYSLTR1 (0.36) | MAOAMAOBGRM5 | |
| SCHEMBL4415080 | 0.73 | MAOB (0.64) | MAOAMAOBGRM5 | |
| SCHEMBL8321628 | 0.73 | CYSLTR1 (0.37) | MAOAMAOBCYP1A2 | |
| SCHEMBL8144365 | 0.72 | MAOA (0.64) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6011033-A | ANTILEUKOTRIENIC ACTION AND ANTIHISTAMINIC ACTION | KOWA CO., LTD. (JP) | 2000-01-04 | — | — | US | disclosed |
| EP-0799826-A1 | Heteroaryl substituted phenylene derivatives, their preparation and their use as leukotriene receptor antagonists | KOWA CO. LTD. (JP) | 1997-10-08 | — | — | EP | disclosed |