SCHEMBL8144292

SCHEMBL8144292

Nc1cc(Oc2c(F)c(Oc3ccc(F)c(N)c3)c(C(F)(F)F)c(F)c2C(F)(F)F)ccc1F

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NR4A1 P22736 1/20 0.37
MAPT P10636 3/20 0.37
POLB P06746 1/20 0.37
HSP90AA1 P07900 1/20 0.37
L3MBTL1 Q9Y468 3/20 0.32
RAB9A P51151 1/20 0.32
SOS1 Q07889 1/20 0.31
CACNA1C Q13936 1/20 0.31
AR P10275 1/20 0.31
ALOX5AP P20292 1/20 0.30
FEN1 P39748 1/20 0.30
LMNA P02545 1/20 0.30
ATM Q13315 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8144265 0.91 MAPT (0.38) NR4A1MAPTPOLBHSP90AA1L3MBTL1
SCHEMBL8137368 0.91 MAPT (0.38) NR4A1MAPTPOLBHSP90AA1L3MBTL1
SCHEMBL8152685 0.85 L3MBTL1 (0.35) NR4A1MAPTPOLBHSP90AA1L3MBTL1
SCHEMBL8146677 0.84 NR4A1 (0.37) NR4A1MAPTPOLBHSP90AA1L3MBTL1
SCHEMBL8138761 0.84 L3MBTL1 (0.38) NR4A1MAPTPOLBHSP90AA1L3MBTL1
SCHEMBL8151920 0.82 POLB (0.31) MAPTPOLBHSP90AA1
SCHEMBL8146628 0.81 NR4A1 (0.35) NR4A1MAPTPOLBHSP90AA1L3MBTL1
SCHEMBL8148126 0.80 MAPT (0.41) NR4A1MAPTPOLBHSP90AA1L3MBTL1
SCHEMBL8147090 0.80 AR (0.36) NR4A1MAPTPOLBHSP90AA1L3MBTL1
SCHEMBL8147527 0.80 L3MBTL1 (0.35) NR4A1MAPTPOLBHSP90AA1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed