Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 4/20 | 0.33 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | ABHD11 | Q8NFV4 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.31 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154568 | 0.91 | DAGLA (0.34) | THRBDAGLAABHD6TP53ALDH1A1 | |
| SCHEMBL8142373 | 0.84 | DAGLA (0.34) | DAGLAABHD6KMT2AMEN1ABHD11 | |
| SCHEMBL8154618 | 0.83 | DAGLA (0.36) | DAGLAABHD6ABHD11 | |
| SCHEMBL8146791 | 0.82 | DAGLB (0.37) | DAGLAABHD6 | |
| SCHEMBL8146211 | 0.82 | KDM4E (0.47) | ALDH1A1MAPK1 | |
| SCHEMBL4167405 | 0.82 | ALDH1A1 (0.38) | THRBDAGLATP53ALDH1A1MAPK1 | |
| SCHEMBL8146332 | 0.81 | NPC1 (0.35) | DAGLAABHD6TP53ALDH1A1TDP1 | |
| SCHEMBL8145765 | 0.79 | KDM4E (0.40) | DAGLAABHD6TP53ALDH1A1SMO | |
| SCHEMBL8150602 | 0.79 | DAGLA (0.35) | DAGLAABHD6ALDH1A1 | |
| SCHEMBL7933772 | 0.77 | DAGLA (0.34) | DAGLAABHD6SMOABHD11PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009003993-A1 | PIPERIDINE DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-01-08 | — | — | WO | disclosed |