DAGLB — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4926864	0.47	8/20
SCHEMBL5784264	0.48	6/20
SCHEMBL6864188	0.78	5/20
SCHEMBL2301024	0.77	5/20
SCHEMBL2296498	0.67	5/20
SCHEMBL2299011	0.66	5/20
SCHEMBL2303563	0.63	5/20
SCHEMBL2300883	0.62	5/20
SCHEMBL2338008	0.62	5/20
SCHEMBL2299052	0.60	5/20
SCHEMBL2298678	0.57	5/20
SCHEMBL2727919	0.40	5/20
SCHEMBL2296963	1.00	4/20
SCHEMBL2296985	1.00	4/20
SCHEMBL2299871	1.00	4/20
SCHEMBL2300753	0.93	4/20
SCHEMBL2296613	0.82	4/20
SCHEMBL2303316	0.81	4/20
SCHEMBL2298284	0.79	4/20
SCHEMBL2299420	0.79	4/20

Clinical trials — most relevant to DAGLB by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency	PHASE3	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Insulin Regulation of Lipolysis and Lipolysis Proteins	EARLY_PHASE1	RECRUITING
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients	nan	COMPLETED
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN
Effect of Cryolipolysis on Insulin Resistance	nan	UNKNOWN
Duality of Lipids: the Athlete's Paradox	nan	COMPLETED
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans	nan	COMPLETED
Free Fatty Acid Induced Insulin Resistance	nan	COMPLETED
Lipidomic and Multi-Omics Profiling of Fatty Liver Disease in People With and Without HIV	nan	NOT_YET_RECRUITING
Lysosomal Acid Lipase (LAL) Deficiency Registry	nan	RECRUITING
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism	nan	COMPLETED
Study of Changes in Skeletal Muscle After Caloric Restriction	nan	ACTIVE_NOT_RECRUITING
Effects of Obesity and Intensity of Exercise on Ghrelin Levels	nan	COMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Fighting Fatty Liver in India	nan	UNKNOWN
Evaluation of Botanicals for Mechanisms Related to Appetite and Fat Metabolism	nan	COMPLETED
Role of Dairy Products in Weight Maintenance	nan	COMPLETED
High Density Lipoprotein Subspecies and Coronary Disease	nan	COMPLETED
Lysosomal Acid Lipase Activity in Nonalcoholic Fatty Liver Disease	nan	COMPLETED
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects)	nan	UNKNOWN
Genetic and Environmental Determinants of Triglycerides (GOLDN)	nan	COMPLETED
Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and Glucose	nan	COMPLETED
Glycemic Index/Saturated Fatty Acid Diet and Hepatic Fat	nan	COMPLETED
The Association of SAA With Apolipoprotein B Affects Cardiovascular Risk	nan	COMPLETED
Tissue Lipids and Insulin Resistance	nan	WITHDRAWN
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a DAGLB binder may also engage these)

Protein	Name	Similarity
P0C1S9	—	1.000	P0C1S9 →
Q91WC9	—	1.000	Q91WC9 →
Q6WQJ1	—	0.985	Q6WQJ1 →
DAGLA	Diacylglycerol lipase-alpha	0.985	landscape →
Q5SNQ7	—	0.984	Q5SNQ7 →
Q3U213	—	0.982	Q3U213 →
Q53P98	—	0.982	Q53P98 →
Q9DFS4	—	0.979	Q9DFS4 →
Q5YLM1	—	0.979	Q5YLM1 →
Q61542	—	0.979	Q61542 →
A2XHJ5	—	0.978	A2XHJ5 →
Q96JX3	—	0.978	Q96JX3 →
Q657S5	—	0.978	Q657S5 →
Q5Z413	—	0.978	Q5Z413 →
Q0DWA9	—	0.978	Q0DWA9 →
Q66K14	—	0.978	Q66K14 →
Q8BXT9	—	0.978	Q8BXT9 →
Q9JIS8	—	0.977	Q9JIS8 →
Q9WTZ2	—	0.977	Q9WTZ2 →
Q92503	—	0.977	Q92503 →
Q640M6	—	0.977	Q640M6 →
Q8BTI9	—	0.977	Q8BTI9 →
ABCC8	ATP-binding cassette sub-family C member 8	0.977	landscape →
Q7Z3F1	—	0.977	Q7Z3F1 →
P0CF65	—	0.977	P0CF65 →
Q2TBM9	—	0.977	Q2TBM9 →
Q9Z2A8	—	0.977	Q9Z2A8 →
Q9WTZ3	—	0.977	Q9WTZ3 →
Q75KP8	—	0.976	Q75KP8 →
DDHD2	Triacylglycerol hydrolase DDHD2	0.976	landscape →