Sugi Predict

Sugi Predict / Compounds / SCHEMBL8145174

SCHEMBL8145174

SCHEMBL8145174

COc1ccc2[nH]nc(C=O)c2c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.53
▸ CYP1A2 P05177 1/20 0.53
▸ CYP2C19 P33261 1/20 0.53
▸ KDM4E B2RXH2 3/20 0.49
▸ MAPT P10636 3/20 0.49
▸ MEN1 O00255 2/20 0.49
▸ KMT2A Q03164 2/20 0.49
▸ HSD17B10 Q99714 2/20 0.49
▸ TSHR P16473 1/20 0.49
▸ GFER P55789 1/20 0.49
▸ TTK P33981 1/20 0.47
▸ HTR2A P28223 1/20 0.46
▸ HTR2C P28335 1/20 0.46
▸ HTR2B P41595 1/20 0.46
▸ PRKAG1 P54619 1/20 0.46
▸ PRKAA1 Q13131 1/20 0.46
▸ PRKAB1 Q9Y478 1/20 0.46
▸ FADS1 O60427 1/20 0.45
▸ DYRK1A Q13627 2/20 0.45
▸ ITK Q08881 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13548686 0.90 TTK (0.46) ALDH1A1CYP1A2CYP2C19KDM4EMAPT
SCHEMBL30481227 0.87 ALDH1A1 (0.53) ALDH1A1CYP1A2CYP2C19KDM4EMAPT
SCHEMBL4802396 0.87 ALDH1A1 (0.53) ALDH1A1CYP1A2CYP2C19KDM4EMAPT
SCHEMBL13548698 0.83 ALDH1A1 (0.45) ALDH1A1CYP1A2CYP2C19TTKACHE
SCHEMBL3536445 0.83 TTK (0.58) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL14735374 0.82 KDM4E (0.46) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL13548700 0.80 KDR (0.56) KMT2ATTKMAOAMAOB
SCHEMBL12515196 0.80 KDM4E (0.46) KDM4EKMT2AGSK3B
SCHEMBL16099536 0.80 KDM4E (0.44) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL13548697 0.79 NTRK1 (0.52) ALDH1A1HTR2AITKLRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735425-A1 COMPOUNDS Psylo Pty Ltd (AU) 2026-05-06 — — EP disclosed
US-20250353818-A1 Compounds Psylo Pty Ltd (AU) 2025-11-20 — — US disclosed
US-12428380-B2 Compounds Psylo Pty Ltd (AU) 2025-09-30 — — US disclosed
US-20250214943-A1 Compounds Psylo Pty Ltd (AU) 2025-07-03 — — US disclosed
US-20250163044-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-05-22 — — US disclosed
WO-2025000053-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-01-02 — — WO disclosed
CN-118974044-A Compounds of formula (I) 赛洛私人有限公司 2024-11-15 — — CN disclosed
EP-4452979-A1 COMPOUNDS Psylo Pty Ltd (AU) 2024-10-30 — — EP disclosed
WO-2023115165-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-06-29 — — WO disclosed
WO-2023115165-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-06-29 — — WO disclosed
EP-2565192-B9 ANTICANCER AGENT UNIV TOKYO (JP) 2015-11-25 — — EP disclosed
US-9156827-B2 Anticancer agent THE UNIVERSITY OF TOKYO (JP) 2015-10-13 — — US disclosed
EP-2565192-B1 ANTICANCER AGENT UNIV TOKYO (JP) 2015-08-12 — — EP disclosed
US-20130102776-A1 ANTICANCER AGENT RIKEN (JP) 2013-04-25 — — US disclosed
EP-2565192-A1 ANTICANCER AGENT The University of Tokyo (JP) 2013-03-06 — — EP disclosed
US-7790722-B2 Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof MEMORY PHARMACEUTICALS CORPORATION (US) 2010-09-07 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-20090088437-A1 INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF XIE WENGE 2009-04-02 — — US disclosed
WO-2000012482-A2 INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY VERNALIS RESEARCH LIMITED (GB) 2000-03-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250214943-A1 Compounds NLN, SLC18A2, PYGB ALDH1A1 981/4885CYP1A2 442/4885CYP2C19 1085/4885
US-12428380-B2 Compounds NLN, SLC18A2, PYGB ALDH1A1 981/4885CYP1A2 442/4885CYP2C19 1085/4885
US-20250163044-A1 COMPOUNDS NLN, SLC18A2, PYGB ALDH1A1 981/4885CYP1A2 442/4885CYP2C19 1085/4885
US-20250353818-A1 Compounds NLN, SLC18A2, PYGB ALDH1A1 981/4885CYP1A2 442/4885CYP2C19 1085/4885
US-20130102776-A1 ANTICANCER AGENT PIM1, PIM3, PIM2 ALDH1A1 1194/4885CYP1A2 2776/4885CYP2C19 2951/4885
US-20090088437-A1 INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF CHRNA7, CHRNA5, CHRNA1 ALDH1A1 701/4885CYP1A2 494/4885CYP2C19 1034/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.