Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29279320 | 0.83 | PTPN1 (0.58) | PTPN1AKR1C3AKR1C2AKR1C1BACE1 | |
| SCHEMBL29022930 | 0.80 | MAPT (0.55) | PTPN1AKR1C3AKR1C2AKR1C1BACE1 | |
| SCHEMBL8003100 | 0.80 | ALDH1A1 (0.56) | PTPN1AKR1C3AKR1C2AKR1C1BACE1 | |
| SCHEMBL5988425 | 0.76 | EGFR (0.62) | PTPN1BACE1EGFRALDH1A1HPGD | |
| SCHEMBL9469340 | 0.75 | PTPN1 (0.63) | PTPN1AKR1C3AKR1C2AKR1C1BACE1 | |
| SCHEMBL28710219 | 0.74 | KDM4E (0.59) | PTPN1AKR1C3AKR1C2AKR1C1BACE1 | |
| SCHEMBL9455582 | 0.74 | CDC25B (0.61) | PTPN1AKR1C3AKR1C2AKR1C1PTPN6 | |
| SCHEMBL11405585 | 0.74 | BACE1 (0.54) | PTPN1AKR1C3AKR1C2AKR1C1BACE1 | |
| SCHEMBL1535921 | 0.73 | BACE1 (0.68) | PTPN1AKR1C3AKR1C2AKR1C1BACE1 | |
| SCHEMBL309670 | 0.73 | PTPN1 (0.67) | PTPN1AKR1C3AKR1C2AKR1C1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017918-A | Phenyl glycine compounds and methods of treating atherosclerosis and restenosis | WARNER-LAMBERT COMPANY (US) | 2000-01-25 | — | — | US | disclosed |