Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | POLA1 | P09884 | 1/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8145294 | 1.00 | MGAM (0.41) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL8924098 | 0.79 | MGAM (0.43) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL8924095 | 0.79 | MGAM (0.43) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL869082 | 0.78 | TSHR (0.53) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL869080 | 0.78 | TSHR (0.53) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL821076 | 0.78 | TSHR (0.53) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL28127344 | 0.78 | TSHR (0.38) | TSHRLMNAHCAR2 | |
| SCHEMBL14287527 | 0.77 | HCAR2 (0.46) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL212257 | 0.77 | HCAR2 (0.55) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL1870774 | 0.77 | HCAR2 (0.55) | MGAMGAASIMGAM2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051590-A | USEFUL AS POTASSIUM CHANNEL INHIBITORS TO TREAT AUTOIMMUNE DISORDERS | MERCK & CO., INC. (US) | 2000-04-18 | — | — | US | disclosed |