Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 10/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8145464 | 0.88 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1CRHR1 | |
| SCHEMBL8152523 | 0.82 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL8147374 | 0.81 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL8152412 | 0.79 | CRHR1 (0.30) | CRHR1 | |
| SCHEMBL8146663 | 0.78 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1CRHR1 | |
| SCHEMBL8148157 | 0.78 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL8146081 | 0.78 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL8152537 | 0.77 | KMT2A (0.39) | CRHR1 | |
| SCHEMBL8154384 | 0.76 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL8139842 | 0.76 | BACE1 (0.38) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994877-A1 | IMIDAZOPYRIMIDINES AND IMIDAZOPYRIDINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Du Pont Pharmaceuticals Company (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001454-A1 | IMIDAZOPYRIMIDINES AND IMIDAZOPYRIDINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-01-14 | — | — | WO | disclosed |