SCHEMBL8146256

SCHEMBL8146256

Nc1cc(Oc2cc(Oc3cc(N)c(F)c(F)c3)c(C(F)(F)F)c(C(F)(F)F)c2F)cc(F)c1F

nearest known ligand 0.32

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
USP2 O75604 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HSP90AA1 P07900 1/20 0.32
HSP90AB1 P08238 1/20 0.32
MAPT P10636 1/20 0.32
THRB P10828 1/20 0.32
G6PD P11413 1/20 0.32
ALOX15 P16050 1/20 0.32
CASP1 P29466 1/20 0.32
KMT2A Q03164 1/20 0.32
HSD17B10 Q99714 1/20 0.32
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8153048 0.91 L3MBTL1 (0.32) L3MBTL1KDM4EMEN1USP2ALDH1A1
SCHEMBL8153275 0.90 L3MBTL1 (0.33) L3MBTL1KDM4EMEN1USP2ALDH1A1
SCHEMBL8152594 0.86 L3MBTL1 (0.32) L3MBTL1MAPTRAB9A
SCHEMBL8145786 0.82 AR (0.32) L3MBTL1RAB9A
SCHEMBL8143651 0.82 RAB9A (0.30) L3MBTL1RAB9A
SCHEMBL8152495 0.82 RAB9A (0.30) L3MBTL1RAB9A
SCHEMBL8144590 0.81 L3MBTL1 (0.32) L3MBTL1KDM4EMEN1USP2ALDH1A1
SCHEMBL8146344 0.81 AR (0.35) L3MBTL1KDM4EMEN1USP2ALDH1A1
SCHEMBL8145456 0.80 RAB9A (0.31) L3MBTL1RAB9A
SCHEMBL8138972 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed