Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.41 |
| ▸ | RAF1 | P04049 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4426603 | 0.73 | MAPK14 (0.53) | MAPK14RAF1MAPTPKM | |
| SCHEMBL3244311 | 0.70 | MAPK14 (0.74) | MAPK14RAF1SMN1; SMN2HTTMAPT | |
| SCHEMBL7624240 | 0.69 | RAF1 (0.40) | MAPK14RAF1 | |
| SCHEMBL4429666 | 0.69 | RAF1 (0.52) | MAPK14RAF1 | |
| SCHEMBL28100026 | 0.67 | TSHR (0.38) | TSHRMAPK14ALDH1A1 | |
| SCHEMBL6049572 | 0.65 | CYP17A1 (0.36) | TSHRMAPK14RAF1SMN1; SMN2HTT | |
| SCHEMBL1304994 | 0.65 | PPARA (0.52) | TSHRSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL13388895 | 0.65 | MAPT (0.43) | TSHRALDH1A1MAPTPKMMEN1 | |
| SCHEMBL3247521 | 0.65 | MAPK14 (0.53) | MAPK14RAF1ALDH1A1MAPT | |
| SCHEMBL23537716 | 0.64 | ALDH1A1 (0.50) | TSHRSMN1; SMN2HTTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019040-A4 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS | BAYER AG (US) | 2000-10-04 | — | — | EP | disclosed |
| EP-1019040-A1 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS | Bayer Corporation (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998052558-A1 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS | BAYER CORPORATION (US) | 1998-11-26 | — | — | WO | disclosed |