SCHEMBL8147248

SCHEMBL8147248

Nc1cc(Oc2c(F)cc(C(F)(F)F)c(Oc3ccc(C(F)(F)F)c(N)c3)c2F)ccc1C(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 1/20 0.35
FEN1 P39748 1/20 0.35
NR4A1 P22736 1/20 0.35
KIF11 P52732 2/20 0.35
POLB P06746 1/20 0.35
HSP90AA1 P07900 1/20 0.35
MAPT P10636 1/20 0.35
AR P10275 7/20 0.34
CYP11B1 P15538 1/20 0.31
CYP11B2 P19099 1/20 0.31
RAB9A P51151 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
SCN9A Q15858 1/20 0.30
SLC7A5 Q01650 2/20 0.30
HTR2A P28223 1/20 0.30
SLC6A4 P31645 1/20 0.30
KCNH2 Q12809 1/20 0.30
EPAS1 Q99814 1/20 0.30
CDK8 P49336 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8146628 0.91 NR4A1 (0.35) ALOX5APFEN1NR4A1KIF11POLB
SCHEMBL8146677 0.84 NR4A1 (0.37) ALOX5APFEN1NR4A1KIF11POLB
SCHEMBL8144092 0.83 AR (0.30) AR
SCHEMBL8138576 0.83
SCHEMBL8145256 0.82 L3MBTL1 (0.39) ALOX5APFEN1NR4A1POLBHSP90AA1
SCHEMBL8145208 0.81 KIF11 (0.37) KIF11POLB
SCHEMBL8148126 0.81 MAPT (0.41) ALOX5APFEN1NR4A1KIF11POLB
SCHEMBL8144370 0.81
SCHEMBL8178499 0.80 NR4A1 (0.54) NR4A1KIF11POLBMAPTAR
SCHEMBL8144954 0.78 NR4A1 (0.52) NR4A1KIF11POLBMAPTAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed