Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609987 | 0.81 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10TPMTLMNA | |
| SCHEMBL14960283 | 0.80 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10TPMTLMNA | |
| SCHEMBL8156118 | 0.78 | TTR (0.40) | ALDH1A1KDM4EHSD17B10GABRPGABRD | |
| SCHEMBL28883701 | 0.74 | ALDH1A1 (0.58) | ALDH1A1KDM4EHSD17B10TPMTLMNA | |
| SCHEMBL1458336 | 0.74 | TPMT (0.61) | ALDH1A1KDM4EHSD17B10TPMTMAPT | |
| SCHEMBL1323406 | 0.71 | ALDH1A1 (0.68) | ALDH1A1KDM4EHSD17B10TPMTLMNA | |
| SCHEMBL9769182 | 0.71 | MAPT (0.39) | ALDH1A1KDM4EHSD17B10MAPTGAA | |
| SCHEMBL22061113 | 0.71 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10TPMTMAPT | |
| SCHEMBL1633542 | 0.71 | CA12 (0.44) | ALDH1A1KDM4ETPMTMAPTLMNA | |
| SCHEMBL613131 | 0.70 | KDM4E (0.47) | ALDH1A1KDM4EHSD17B10TPMTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686145-B1 | NEW COMPOUNDS | UNIV MARYLAND (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5883129-A | Hydroxylated anthranilic acid derivatives | ASTRA AKTIEBOLAG (SE) | 1999-03-16 | — | — | US | disclosed |
| US-5523475-A | New compounds | AKTIEBOLAGET ASTRA (SE) | 1996-06-04 | — | — | US | disclosed |
| EP-0686145-A1 | NEW COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019316-A1 | NEW COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1994-09-01 | — | — | WO | disclosed |