SCHEMBL8147694

SCHEMBL8147694

Nc1cc(Oc2ccc(C(F)(F)F)c(Oc3cc(N)c(C(F)(F)F)c(F)c3F)c2)c(F)c(F)c1C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
AR P10275 13/20 0.36
HTR2A P28223 1/20 0.36
SLC6A4 P31645 1/20 0.36
KCNH2 Q12809 1/20 0.36
L3MBTL1 Q9Y468 3/20 0.35
MAPT P10636 2/20 0.35
LMNA P02545 1/20 0.35
ATM Q13315 1/20 0.35
RAB9A P51151 1/20 0.35
NPSR1 Q6W5P4 1/20 0.33
ALOX5AP P20292 1/20 0.32
FEN1 P39748 1/20 0.32
SCN9A Q15858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8147512 0.89 AR (0.36) ARHTR2ASLC6A4KCNH2L3MBTL1
SCHEMBL8152049 0.88 AR (0.38) ARHTR2ASLC6A4KCNH2L3MBTL1
SCHEMBL8151871 0.83 AR (0.39) ARHTR2ASLC6A4KCNH2L3MBTL1
SCHEMBL8147333 0.82 AR (0.39) ARHTR2ASLC6A4KCNH2ALOX5AP
SCHEMBL8137088 0.81 AR (0.40) ARHTR2ASLC6A4KCNH2L3MBTL1
SCHEMBL8138774 0.81 L3MBTL1 (0.36) ARHTR2ASLC6A4KCNH2L3MBTL1
SCHEMBL8138484 0.81 AR (0.42) ARHTR2ASLC6A4KCNH2L3MBTL1
SCHEMBL8139029 0.81 NR4A1 (0.40) ARHTR2ASLC6A4KCNH2L3MBTL1
SCHEMBL8138439 0.80 L3MBTL1 (0.39) ARL3MBTL1MAPTLMNAATM
SCHEMBL8147453 0.80 L3MBTL1 (0.43) ARHTR2ASLC6A4KCNH2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed