SCHEMBL8147453

SCHEMBL8147453

Nc1cc(C(F)(F)F)cc(Oc2ccc(C(F)(F)F)c(Oc3cc(C(F)(F)F)cc(N)c3F)c2)c1F

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.43
RAB9A P51151 1/20 0.43
MAPT P10636 2/20 0.41
LMNA P02545 1/20 0.41
ATM Q13315 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
AR P10275 6/20 0.36
HTR2A P28223 1/20 0.34
SLC6A4 P31645 1/20 0.34
KCNH2 Q12809 1/20 0.34
USP2 O75604 1/20 0.33
KMT2A Q03164 1/20 0.33
SCN8A Q9UQD0 1/20 0.33
SCN10A Q9Y5Y9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8137088 0.87 AR (0.40) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8145238 0.86 L3MBTL1 (0.43) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8152049 0.85 AR (0.38) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8150920 0.81 AR (0.43) L3MBTL1MAPTNPSR1AR
SCHEMBL8146088 0.81 NR4A1 (0.40) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8147512 0.80 AR (0.36) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8147694 0.80 AR (0.36) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8323909 0.80 L3MBTL1 (0.38) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL8138014 0.79 AR (0.38) L3MBTL1RAB9AARHTR2ASLC6A4
SCHEMBL8151840 0.79 L3MBTL1 (0.33) L3MBTL1RAB9AMAPTLMNAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed