Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 5/20 | 0.48 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | CKS1B | P61024 | 2/20 | 0.44 |
| ▸ | SKP1 | P63208 | 2/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.44 |
| ▸ | PGK1 | P00558 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8146095 | 0.84 | ZAP70 (0.58) | ZAP70PRKD3EGFRPRKCGPRKCB | |
| SCHEMBL6955414 | 0.80 | ZAP70 (0.55) | ZAP70WNT3ACCNA2CDK2CDK9 | |
| SCHEMBL8148420 | 0.78 | WNT3A (0.49) | ZAP70WNT3ACCNA2CDK2CDK9 | |
| SCHEMBL8148421 | 0.78 | WNT3A (0.49) | ZAP70WNT3ADYRK2PRKD3EGFR | |
| SCHEMBL18412549 | 0.73 | JAK2 (0.54) | CCNA2CDK2CDK9CCNT1CCNA1 | |
| SCHEMBL21553394 | 0.73 | ACVR1 (0.71) | — | |
| SCHEMBL29351633 | 0.73 | ACVR1 (0.71) | — | |
| SCHEMBL6950816 | 0.72 | RET (0.54) | WNT3ARETCKS1BSKP1SKP2 | |
| SCHEMBL8145178 | 0.70 | HDAC1 (0.46) | ZAP70CCNA2CDK2CDK9CCNT1 | |
| SCHEMBL20966312 | 0.70 | TGFBR1 (0.48) | CNR2RAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6093716-A | Substituted 2-pyrimidineamines and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |
| EP-0929549-A1 | SUBSTITUTED 2-PYRIMIDINEAMINES, THEIR PREPARATION AND THEIR USE AS PROTEINE KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998011095-A1 | SUBSTITUTED 2-PYRIMIDINEAMINES, THEIR PREPARATION AND THEIR USE AS PROTEINE KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-03-19 | — | — | WO | disclosed |