Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 5/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8142488 | 0.90 | NOTUM (0.46) | PDK2ARPGRNOTUMKMT2A | |
| SCHEMBL8326418 | 0.87 | NOTUM (0.43) | PDK2ARNOTUMKMT2A | |
| SCHEMBL8155327 | 0.84 | PTGS2 (0.54) | PTGS2PDK2EGFRMEN1KMT2A | |
| SCHEMBL36203 | 0.83 | PTGS2 (0.55) | PTGS2PDK2EGFRNOTUMACLY | |
| SCHEMBL19125475 | 0.83 | PTGS2 (0.55) | PTGS2PDK2EGFRNOTUMACLY | |
| SCHEMBL402630 | 0.83 | NOTUM (0.43) | NOTUMKMT2A | |
| SCHEMBL18822403 | 0.77 | PTGS2 (0.50) | PTGS2PDK2EGFRNOTUMKMT2A | |
| SCHEMBL21083536 | 0.76 | EGFR (0.64) | PTGS2EGFRMEN1KMT2A | |
| SCHEMBL30849990 | 0.76 | EGFR (0.64) | PTGS2EGFRMEN1KMT2A | |
| SCHEMBL6741308 | 0.76 | EGFR (0.61) | PTGS2PDK2EGFRACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6077853-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 2000-06-20 | — | — | US | disclosed |
| EP-0951285-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998029119-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1998-07-09 | — | — | WO | disclosed |