Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8142488 | 0.96 | NOTUM (0.46) | NOTUMMAPTALDH1A1HPGDCYP2C9 | |
| SCHEMBL402630 | 0.94 | NOTUM (0.43) | NOTUMMAPTALDH1A1HPGDCYP2C9 | |
| SCHEMBL8149043 | 0.87 | PTGS2 (0.47) | NOTUMKMT2APDK2AR | |
| SCHEMBL6965305 | 0.81 | ALDH1A1 (0.43) | MAPTALDH1A1HPGDCYP2C9PLA2G7 | |
| SCHEMBL338554 | 0.81 | SMN1; SMN2 (0.46) | MAPTALDH1A1HPGDKDM4ECA12 | |
| SCHEMBL31238876 | 0.81 | MAPT (0.57) | NOTUMMAPTALDH1A1CYP2C9KMT2A | |
| SCHEMBL3909726 | 0.81 | ALDH1A1 (0.51) | ALDH1A1HPGDPLA2G7CA12CA1 | |
| SCHEMBL2934710 | 0.81 | MAPT (0.57) | NOTUMMAPTALDH1A1CYP2C9KMT2A | |
| SCHEMBL31336381 | 0.81 | MAPT (0.57) | NOTUMMAPTALDH1A1HPGDCYP2C9 | |
| SCHEMBL4580602 | 0.81 | MAPT (0.57) | NOTUMMAPTALDH1A1HPGDCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951285-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998029119-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1998-07-09 | — | — | WO | disclosed |