Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 13/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677947 | 0.90 | SIRT2 (0.39) | SIRT2 | |
| SCHEMBL8155410 | 0.89 | CYP19A1 (0.47) | SIRT2CYP19A1FNTAFNTBPGGT1B | |
| SCHEMBL8157361 | 0.89 | CYP19A1 (0.47) | SIRT2CYP19A1 | |
| SCHEMBL8155533 | 0.87 | FNTA (0.41) | SIRT2FNTAFNTBPGGT1B | |
| SCHEMBL8150875 | 0.84 | FNTA (0.39) | SIRT2FNTAFNTBPGGT1B | |
| SCHEMBL2787690 | 0.84 | CYP19A1 (0.40) | SIRT2MAOBCYP19A1 | |
| SCHEMBL7669884 | 0.83 | SIRT2 (0.40) | SIRT2CYP19A1 | |
| SCHEMBL5688738 | 0.77 | SIRT2 (0.46) | SIRT2ENPP2 | |
| SCHEMBL7675181 | 0.77 | SIRT2 (0.41) | SIRT2MAOBENPP2 | |
| SCHEMBL7663646 | 0.77 | L3MBTL1 (0.45) | SIRT2MAOBMAOAENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6077853-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 2000-06-20 | — | — | US | disclosed |
| EP-0951285-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| US-5939439-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-08-17 | — | — | US | disclosed |
| WO-1998029119-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1998-07-09 | — | — | WO | disclosed |