SCHEMBL8150241

SCHEMBL8150241

CO[SiH](OC)C(CCCS)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 7/20 0.41
HTR2A P28223 7/20 0.41
MMP13 P45452 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
FOLH1 Q04609 3/20 0.36
SIGMAR1 Q99720 1/20 0.35
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC10 Q969S8 1/20 0.34
HDAC11 Q96DB2 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
HDAC9 Q9UKV0 1/20 0.34
HDAC5 Q9UQL6 1/20 0.34
CHRM2 P08172 1/20 0.33
HTR1A P08908 1/20 0.33
ADRA2A P08913 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19470844 0.84 POLB (0.40) HTR2ASIGMAR1OPRM1KCNH2LMNA
SCHEMBL3110907 0.84 SIGMAR1 (0.40) HTR2ASIGMAR1OPRM1LMNA
SCHEMBL19470821 0.83 HTR2A (0.41) HTR2ASIGMAR1OPRM1KCNH2
SCHEMBL19470838 0.83 HTR2A (0.41) HTR2ASIGMAR1OPRM1KCNH2
SCHEMBL19470845 0.83 HTR2A (0.41) HTR2ASIGMAR1OPRM1KCNH2
SCHEMBL19470848 0.83 HTR2A (0.41) HTR2ASIGMAR1OPRM1KCNH2
SCHEMBL704370 0.80 AOC3 (0.40) HRH1HTR2ASIGMAR1OPRM1LMNA
SCHEMBL21630243 0.79 HTR2A (0.56) HRH1HTR2ATDP1CHRM2HTR1A
SCHEMBL2244555 0.79 HRH1 (0.50) HRH1HTR2ASLC6A2SLC6A4SLC6A3
SCHEMBL9157825 0.78 SIGMAR1 (0.32) HRH1HTR2ASIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6051665-A A FLUOROPOLYMER IS OBTAINED FROM THE MONOMER SELECTED FROM THE GROUP CONTAINING A FLUORO-OLEFIN, A FLUORO VINYL ETHER, A FLUORO (METH) ACRYLATE AND MIXTURE, ALSO CONTAIN HYDROLYZABLE SILYL GROUP, A SILOXY COMPOUND AND A CHELATE COMPLEX JSR CORPORATION (JP) 2000-04-18 US disclosed