SCHEMBL8150654

SCHEMBL8150654

Nc1cc(Oc2ccc(C(F)(F)F)c(Oc3cc(N)c(C(F)(F)F)cc3F)c2)c(F)cc1C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
AR P10275 12/20 0.44
HTR2A P28223 1/20 0.38
SLC6A4 P31645 1/20 0.38
KCNH2 Q12809 1/20 0.38
L3MBTL1 Q9Y468 3/20 0.36
RAB9A P51151 1/20 0.36
SCN9A Q15858 1/20 0.36
EPAS1 Q99814 1/20 0.35
KIF11 P52732 1/20 0.35
MAPT P10636 2/20 0.34
LMNA P02545 1/20 0.34
ATM Q13315 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8138439 0.92 L3MBTL1 (0.39) ARL3MBTL1RAB9AMAPTLMNA
SCHEMBL8145661 0.91 AR (0.44) ARHTR2ASLC6A4KCNH2L3MBTL1
SCHEMBL8138484 0.89 AR (0.42) ARHTR2ASLC6A4KCNH2L3MBTL1
SCHEMBL8146648 0.86 AR (0.45) ARHTR2ASLC6A4KCNH2L3MBTL1
SCHEMBL8144489 0.86 L3MBTL1 (0.39) ARL3MBTL1RAB9AMAPTLMNA
SCHEMBL8144909 0.84 L3MBTL1 (0.43) ARL3MBTL1RAB9AMAPTLMNA
SCHEMBL8152279 0.84 KDM4E (0.36) ARHTR2AL3MBTL1KIF11MAPT
SCHEMBL8145008 0.82 NR4A1 (0.45) ARL3MBTL1RAB9AMAPTLMNA
SCHEMBL8137755 0.82 NR4A1 (0.45) ARL3MBTL1RAB9AMAPTLMNA
SCHEMBL8144289 0.82 L3MBTL1 (0.46) ARL3MBTL1RAB9AMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed