Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | DRD4 | P21917 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.61 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5582704 | 0.92 | MCHR1 (0.70) | NPC1RAB9ASMN1; SMN2MCHR1MAPT | |
| SCHEMBL2087431 | 0.90 | ALDH1A1 (0.62) | NPC1RAB9ASMN1; SMN2SETD7ALDH1A1 | |
| Hydrochloric Acid SCHEMBL20547794 | 0.88 | ALDH1A1 (0.60) | NPC1RAB9ASMN1; SMN2SETD7ALDH1A1 | |
| SCHEMBL8484244 | 0.88 | MCHR1 (0.54) | NPC1RAB9ASMN1; SMN2DRD2DRD4 | |
| SCHEMBL30046741 | 0.88 | ALDH1A1 (0.73) | SMN1; SMN2SETD7ALDH1A1HPGDTHRB | |
| Hydrochloric Acid SCHEMBL8483231 | 0.87 | MCHR1 (0.53) | NPC1RAB9ASMN1; SMN2DRD2DRD4 | |
| SCHEMBL24061100 | 0.86 | HTT (0.57) | SMN1; SMN2DRD2DRD4DRD3MCHR1 | |
| SCHEMBL3145464 | 0.84 | SETD7 (0.52) | NPC1RAB9ASMN1; SMN2DRD2DRD4 | |
| SCHEMBL3141624 | 0.84 | SETD7 (0.58) | SMN1; SMN2DRD2DRD4DRD3MCHR1 | |
| SCHEMBL21551978 | 0.84 | TP53 (0.62) | NPC1RAB9AMCHR1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042855-A1 | BENZAMIDE mGluR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | DEPARTMENT OF VETERANS AFFAIRS | 2009-02-12 | — | — | US | disclosed |
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042855-A1 | BENZAMIDE mGluR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM3 | NPC1 2371/4885RAB9A 3119/4885SMN1; SMN2 2385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.