Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8152393 | 0.84 | NPC1 (0.53) | KMT2AMEN1MAPTHPGDKDM4E | |
| SCHEMBL3097256 | 0.79 | KMT2A (0.60) | KMT2AMEN1MAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL9244391 | 0.78 | KMT2A (0.59) | KMT2AMEN1MAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL5168028 | 0.77 | PGR (0.52) | KMT2AMEN1MAPTCYP3A4MAPK1 | |
| SCHEMBL23238 | 0.77 | PGR (0.52) | KMT2AMEN1MAPTCYP3A4MAPK1 | |
| SCHEMBL1699093 | 0.77 | KMT2A (0.64) | KMT2AMEN1MAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL9155651 | 0.76 | KMT2A (0.62) | KMT2AMEN1MAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL11689197 | 0.76 | KMT2A (0.57) | KMT2AMEN1MAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL3539680 | 0.76 | CES2 (0.39) | KMT2AMEN1MAPTSMN1; SMN2HPGD | |
| Benzene SCHEMBL28162079 | 0.76 | PGR (0.50) | KMT2AMEN1MAPTCYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028202-A | ANTIINFLAMMATORY AGENTS INHIBITING THE PRODUCTION OF ARACHIDONIC ACID PRODUCTS ASSOCIATED WITH 5-LIPOXYGENASE AND CYCLOOXYGENASE | ORTHO PHARMACEUTICAL CORPORATION (US) | 2000-02-22 | — | — | US | disclosed |
| US-5925769-A | INHIBIT 5-LIPOXYGENASE AND/OR CYCLOOXYGENASE | ORTHO PHARMACEUTICAL, CORP. (US) | 1999-07-20 | — | — | US | disclosed |