Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8135372 | 0.88 | MEN1 (0.50) | MEN1KMT2ATRPV1KCNJ6KCNJ5 | |
| SCHEMBL8123349 | 0.87 | MEN1 (0.45) | MEN1KMT2ATRPV1KDM4EALDH1A1 | |
| SCHEMBL8151959 | 0.86 | MAPT (0.38) | GAAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8061142 | 0.85 | KDM4E (0.44) | FLT3MAP4K1MEN1KMT2AIMPDH2 | |
| SCHEMBL8155111 | 0.85 | ELANE (0.41) | MEN1KMT2AELANE | |
| SCHEMBL8130779 | 0.83 | CDK2 (0.41) | FLT3GAAMEN1KMT2AKDM4E | |
| SCHEMBL8131769 | 0.83 | SRC (0.37) | KMT2AKCNJ6KCNJ5KCNJ3KDM4E | |
| SCHEMBL8143616 | 0.80 | ALDH1A1 (0.44) | MEN1KMT2ATRPV1KDM4EALDH1A1 | |
| SCHEMBL8157823 | 0.80 | MEN1 (0.43) | FLT3MAP4K1GAAMEN1KMT2A | |
| SCHEMBL8149715 | 0.80 | IDO1 (0.36) | GAAMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |