Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8130779 | 0.90 | CDK2 (0.41) | MAPTKDM4EALDH1A1TP53KMT2A | |
| SCHEMBL8131769 | 0.89 | SRC (0.37) | MAPTSMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL8153984 | 0.87 | SMN1; SMN2 (0.35) | MAPTSMN1; SMN2KDM4EPOLBALDH1A1 | |
| SCHEMBL8151033 | 0.86 | FLT3 (0.41) | SMN1; SMN2KDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL8060382 | 0.85 | KDM4E (0.46) | MAPTSMN1; SMN2KDM4EPOLBALDH1A1 | |
| SCHEMBL8135372 | 0.85 | MEN1 (0.50) | MAPTSMN1; SMN2POLBALDH1A1TP53 | |
| SCHEMBL8123349 | 0.82 | MEN1 (0.45) | MAPTSMN1; SMN2KDM4EPOLBALDH1A1 | |
| SCHEMBL8143616 | 0.82 | ALDH1A1 (0.44) | MAPTSMN1; SMN2KDM4EPOLBALDH1A1 | |
| SCHEMBL8149896 | 0.80 | MEN1 (0.43) | MAPTSMN1; SMN2KDM4EPOLBALDH1A1 | |
| SCHEMBL8152609 | 0.80 | CTNNB1 (0.34) | MAPTSMN1; SMN2KDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | claimed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | claimed |
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |