SCHEMBL8152033

SCHEMBL8152033

Nc1cc(Oc2cc(Oc3cc(N)c(C(F)(F)F)c(C(F)(F)F)c3)cc(C(F)(F)F)c2)cc(C(F)(F)F)c1C(F)(F)F

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.34
MAPT P10636 3/20 0.34
NPSR1 Q6W5P4 1/20 0.34
RAB9A P51151 1/20 0.33
AR P10275 1/20 0.33
PTPN5 P54829 2/20 0.32
TLR8 Q9NR97 2/20 0.32
NR4A1 P22736 1/20 0.31
LMNA P02545 1/20 0.31
ATM Q13315 1/20 0.31
ALDH1A1 P00352 2/20 0.31
IDO1 P14902 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8146207 0.86 AR (0.44) L3MBTL1MAPTRAB9AARNR4A1
SCHEMBL8147195 0.85 MAPT (0.43) L3MBTL1MAPTNPSR1RAB9AAR
SCHEMBL8150901 0.83 L3MBTL1 (0.33) L3MBTL1MAPTNPSR1RAB9AAR
SCHEMBL8151759 0.82 MAPT (0.34) L3MBTL1MAPTNPSR1RAB9AAR
SCHEMBL8152179 0.81 L3MBTL1 (0.35) L3MBTL1MAPTNPSR1RAB9AAR
SCHEMBL8145122 0.79 NR4A1 (0.44) L3MBTL1MAPTNPSR1RAB9AAR
SCHEMBL8152824 0.79 NR4A1 (0.44) L3MBTL1MAPTNPSR1RAB9AAR
SCHEMBL27082431 0.79 PTPN5 (0.42) L3MBTL1MAPTRAB9APTPN5LMNA
SCHEMBL28577674 0.79 NR4A1 (0.42) L3MBTL1MAPTNPSR1RAB9AAR
SCHEMBL8147716 0.79 L3MBTL1 (0.40) L3MBTL1MAPTNPSR1RAB9AAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed