SCHEMBL8147195

SCHEMBL8147195

Nc1cc(Oc2cccc(Oc3cc(N)c(C(F)(F)F)c(C(F)(F)F)c3)c2)cc(C(F)(F)F)c1C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
ALDH1A1 P00352 2/20 0.43
MITF O75030 1/20 0.43
GAA P10253 1/20 0.43
GFER P55789 1/20 0.43
NLRP1 Q9C000 1/20 0.43
NOD2 Q9HC29 1/20 0.43
NPSR1 Q6W5P4 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
AR P10275 6/20 0.41
NR4A1 P22736 1/20 0.38
MAOB P27338 1/20 0.38
LOX P28300 1/20 0.36
LOXL2 Q9Y4K0 1/20 0.36
F10 P00742 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8146207 0.88 AR (0.44) MAPTSMN1; SMN2MEN1KMT2AALDH1A1
SCHEMBL8145996 0.85 L3MBTL1 (0.38) MAPTALDH1A1GAANPSR1L3MBTL1
SCHEMBL8152033 0.85 L3MBTL1 (0.34) MAPTALDH1A1NPSR1L3MBTL1AR
SCHEMBL8147716 0.84 L3MBTL1 (0.40) MAPTSMN1; SMN2MEN1KMT2AALDH1A1
SCHEMBL8139029 0.84 NR4A1 (0.40) MAPTNPSR1L3MBTL1ARNR4A1
SCHEMBL8146540 0.82 MAPT (0.48) MAPTSMN1; SMN2MEN1KMT2AALDH1A1
SCHEMBL8150901 0.81 L3MBTL1 (0.33) MAPTMEN1KMT2AALDH1A1NPSR1
SCHEMBL29518504 0.81 ALDH1A1 (0.52) MAPTSMN1; SMN2MEN1KMT2AALDH1A1
SCHEMBL8138160 0.81 MAPT (0.52) MAPTSMN1; SMN2MEN1KMT2AALDH1A1
SCHEMBL8146642 0.81 ALDH1A1 (0.52) MAPTSMN1; SMN2MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed