Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6785452 | 0.94 | RXFP1 (0.44) | RXFP1CA1CA2CA9ADRA2A | |
| SCHEMBL6609264 | 0.88 | RXFP1 (0.49) | RXFP1CA1CA2CA9ALDH1A1 | |
| SCHEMBL6790611 | 0.84 | RXFP1 (0.43) | RXFP1CA1CA2CA9MAPT | |
| SCHEMBL6781068 | 0.83 | RXFP1 (0.40) | RXFP1ALDH1A1POLBACACB | |
| SCHEMBL6781079 | 0.82 | MAPT (0.42) | RXFP1CA1CA2CA9MAPT | |
| SCHEMBL6784074 | 0.82 | KDM4E (0.42) | APEX1MYCALDH1A1GRIA1GRIA2 | |
| SCHEMBL7983593 | 0.79 | RXFP1 (0.43) | RXFP1CA1CA2CA9MAPT | |
| SCHEMBL6610930 | 0.79 | NPC1 (0.40) | APEX1ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL14287202 | 0.79 | ALDH1A1 (0.40) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8126976 | 0.79 | GRIA1 (0.36) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781285-B1 | FUSED INDOLE AND QUINOXALINE DERIVATIVES, THEIR PREPARATION AND USE AS GLUTAMATE ANTAGONISTS | NEUROSEARCH AS (DK) | 2000-01-12 | — | — | EP | disclosed |
| US-5801174-A | CEREBROVASCULAR DISORDERS | NEUROSEARCH A/S (DK) | 1998-09-01 | — | — | US | disclosed |
| EP-0664807-B1 | QUINOXALINEDIONE DERIVATIVES AS EAA ANTAGONISTS | WARNER LAMBERT CO (US) | 1997-09-10 | — | — | EP | disclosed |