Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 2/20 | 0.35 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6785452 | 0.82 | RXFP1 (0.44) | KDM4EHSD17B10GRIA1GRIA2GRIA3 | |
| SCHEMBL8152134 | 0.82 | RXFP1 (0.44) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL6610930 | 0.80 | NPC1 (0.40) | KDM4EALDH1A1APEX1ADORA1UHRF1 | |
| SCHEMBL8807579 | 0.79 | UHRF1 (0.35) | KDM4EHSD17B10GRIA1GRIA2GRIA3 | |
| SCHEMBL8807587 | 0.78 | UHRF1 (0.35) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL10967773 | 0.75 | ADRA2A (0.46) | ALDH1A1POLBNPC1RAB9A | |
| SCHEMBL8810234 | 0.74 | POLB (0.34) | KDM4EHSD17B10GRIA1GRIA2GRIA3 | |
| SCHEMBL6784777 | 0.74 | NPC1 (0.51) | ALDH1A1NPC1RAB9A | |
| SCHEMBL9289909 | 0.73 | APEX1 (0.38) | KDM4EALDH1A1PTPN2PTPN1APEX1 | |
| SCHEMBL6609264 | 0.72 | RXFP1 (0.49) | KDM4EHSD17B10ALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6703391-B2 | THROMBOSIS, BRAIN DISORDERS, CARDIOVASCULAR DISORDERS, ALZHEIMER'S DISEASE, HUNTINGTON DISEASES | NEUROSEARCH A/S (DK) | 2004-03-09 | — | — | US | disclosed |
| EP-0664807-B1 | QUINOXALINEDIONE DERIVATIVES AS EAA ANTAGONISTS | WARNER LAMBERT CO (US) | 1997-09-10 | — | — | EP | disclosed |