SCHEMBL8152244

SCHEMBL8152244

Nc1cc(F)c(F)c(Oc2ccc(C(F)(F)F)c(Oc3cc(N)cc(F)c3F)c2)c1

nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
AR P10275 15/20 0.40
KIF11 P52732 1/20 0.37
HTR2A P28223 1/20 0.37
SLC6A4 P31645 1/20 0.37
KCNH2 Q12809 1/20 0.37
SCN9A Q15858 1/20 0.35
ALOX5AP P20292 1/20 0.33
FEN1 P39748 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8138014 0.90 AR (0.38) ARKIF11HTR2ASLC6A4KCNH2
SCHEMBL8147729 0.87 AR (0.39) ARKIF11HTR2ASLC6A4KCNH2
SCHEMBL8137251 0.85 AR (0.40) ARKIF11HTR2ASLC6A4KCNH2
SCHEMBL8145930 0.84 GAA (0.46) ARKIF11
SCHEMBL8153041 0.84 AR (0.32) ARKIF11
SCHEMBL8138832 0.84 KIF11 (0.41) ARKIF11HTR2ASLC6A4KCNH2
SCHEMBL8145810 0.83 KIF11 (0.35) ARKIF11HTR2A
SCHEMBL8152049 0.81 AR (0.38) ARHTR2ASLC6A4KCNH2SCN9A
SCHEMBL8151144 0.81 GLA (0.36) ARHTR2ASLC6A4KCNH2
SCHEMBL8144223 0.80 KIF11 (0.33) ARKIF11HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed