Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11855077 | 0.77 | MEN1 (0.45) | DRD2MEN1KMT2AKDM4ECYP3A4 | |
| SCHEMBL13306274 | 0.76 | — | — | |
| SCHEMBL4781902 | 0.76 | NPSR1 (0.60) | DRD2DRD4SIRT2SIRT1SIRT3 | |
| SCHEMBL8136808 | 0.75 | DRD2 (0.43) | DRD2DRD4SIRT2SIRT1SIRT3 | |
| SCHEMBL30832821 | 0.74 | GFER (0.44) | MEN1KMT2AKDM4ECYP1A2HDAC2 | |
| SCHEMBL18361885 | 0.73 | NPC1 (0.56) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL84810 | 0.73 | NPC1 (0.61) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL11815703 | 0.73 | MAPT (0.43) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5718185 | 0.73 | — | — | |
| SCHEMBL8144205 | 0.72 | DRD2 (0.43) | DRD2DRD4SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |