Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153224 | 0.75 | DRD2 (0.45) | DRD2DRD4SIRT2SIRT1SIRT3 | |
| SCHEMBL13306274 | 0.73 | — | — | |
| SCHEMBL4781902 | 0.73 | NPSR1 (0.60) | DRD2DRD4SIRT2SIRT1SIRT3 | |
| SCHEMBL8144205 | 0.72 | DRD2 (0.43) | DRD2DRD4SIRT2SIRT1SIRT3 | |
| SCHEMBL8146862 | 0.70 | DRD2 (0.62) | DRD2DRD4 | |
| SCHEMBL8143085 | 0.69 | DRD2 (0.43) | DRD2DRD4SIRT2SIRT1SIRT3 | |
| SCHEMBL25150721 | 0.69 | NPSR1 (0.55) | DRD2DRD4SIRT2SIRT1SIRT3 | |
| SCHEMBL6485089 | 0.69 | NPSR1 (0.45) | DRD2DRD4SIRT2SIRT1SIRT3 | |
| SCHEMBL2091285 | 0.69 | HDAC2 (0.54) | DRD2DRD4HDAC2HDAC8HDAC6 | |
| SCHEMBL8139006 | 0.67 | NPSR1 (0.52) | DRD2DRD4HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |