Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153479 | 1.00 | ALOX5 (0.34) | ALOX5PTGS1PTGS2 | |
| SCHEMBL8155049 | 0.80 | PTGS1 (0.38) | ALOX5PTGS1PTGS2 | |
| SCHEMBL8155046 | 0.80 | PTGS1 (0.38) | ALOX5PTGS1PTGS2 | |
| SCHEMBL8146384 | 0.74 | GABBR2 (0.38) | ALOX5PTGS1PTGS2 | |
| SCHEMBL14452703 | 0.69 | GABBR2 (0.37) | — | |
| SCHEMBL12020341 | 0.65 | GABBR2 (0.36) | PTGS1PTGS2 | |
| SCHEMBL27744598 | 0.64 | GABBR2 (0.40) | PTGS1PTGS2 | |
| SCHEMBL14497176 | 0.63 | GABBR2 (0.39) | ALOX5PTGS1PTGS2 | |
| SCHEMBL21880335 | 0.63 | PTGS1 (0.39) | PTGS1PTGS2 | |
| SCHEMBL31028101 | 0.63 | PIK3CA (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6083977-A | HAVING ACTIVITY FOR RETINOIC ACID RECEPTORS AND RETINOID X RECEPTORS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2000-07-04 | — | — | US | disclosed |
| EP-0800503-B1 | NOVEL TRIENOIC RETINOID COMPOUNDS AND METHODS | LIGAND PHARM INC (US) | 2000-05-10 | — | — | EP | disclosed |
| US-5721103-A | SKIN DISORDERS; VISION DEFECTS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0800503-A1 | NOVEL TRIENOIC RETINOID COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS, INC. (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020913-A1 | NOVEL TRIENOIC RETINOID COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1996-07-11 | — | — | WO | disclosed |