Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | HPGD | P15428 | 1/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.75 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.73 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | CA2 | P00918 | 2/20 | 0.66 |
| ▸ | CA1 | P00915 | 1/20 | 0.66 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.63 |
| ▸ | SNCA | P37840 | 1/20 | 0.62 |
| ▸ | JUN | P05412 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153880 | 1.00 | KDM4E (0.75) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL30560923 | 1.00 | KDM4E (0.75) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL28422571 | 0.92 | KDM4E (0.65) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL28393232 | 0.91 | JUN (0.78) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL29407280 | 0.89 | HDAC1 (0.64) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL8497323 | 0.89 | JUN (0.71) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL21986836 | 0.88 | KDM4E (0.59) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL18049432 | 0.88 | APP (0.65) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL18049430 | 0.88 | APP (0.65) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL2951016 | 0.88 | CYP2D6 (0.77) | KDM4EALDH1A1HPGDALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4134028-A | — | — | None | — | — | JP | disclosed |
| CN-107531686-B | Inhibitors of pseudomonas aeruginosa LecB | 亥姆霍兹感染研究中心有限责任公司 | 2021-07-09 | — | — | CN | disclosed |
| US-10407398-B2 | Inhibitors of Pseudomonas aeruginosa LecB | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2019-09-10 | — | — | US | disclosed |
| CN-109652275-A | A kind of distiller's yeast and preparation method thereof containing Chinese herbal medicine | 安龙县汪氏土酒厂 | 2019-04-19 | — | — | CN | disclosed |
| US-20180155310-A1 | INHIBITORS OF PSEUDOMONAS AERUGINOSA LECB | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2018-06-07 | — | — | US | disclosed |
| EP-3274341-A1 | INHIBITORS OF PSEUDOMONAS AERUGINOSA LECB | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2018-01-31 | — | — | EP | disclosed |
| CN-107531686-A | Pseudomonas aeruginosa LecB inhibitor | 亥姆霍兹感染研究中心有限责任公司 | 2018-01-02 | — | — | CN | disclosed |
| WO-2016151066-A1 | INHIBITORS OF PSEUDOMONAS AERUGINOSA LECB | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2016-09-29 | — | — | WO | disclosed |
| CN-105646439-A | Synergist for antifungal drugs, and preparation and application thereof | 中国人民解放军第二军医大学 | 2016-06-08 | — | — | CN | disclosed |
| US-RE36625-E | Linear and cyclic polymers or oligomers having a photoreactive ethene group | ROLIC AG (CH) | 2000-03-21 | — | — | US | disclosed |
| US-5539074-A | LIQUID CRYSTAL POLYMERS ON SILICA FOR LIGHT SENSITIVE ELEMENTS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-23 | — | — | US | disclosed |
| JP-H04134028-A | CEREBRAL FUNCTION-IMPROVING DRUG AND ANTIDEPRESSANT | KANEGAFUCHI CHEM IND CO LTD | 1992-05-07 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155310-A1 | INHIBITORS OF PSEUDOMONAS AERUGINOSA LECB | FUCA1, ALG1, FUCA2 | KDM4E 3076/4885ALDH1A1 1951/4885HPGD 2893/4885 |
| US-10407398-B2 | Inhibitors of Pseudomonas aeruginosa LecB | FUCA1, ALG1, FUCA2 | KDM4E 3076/4885ALDH1A1 1951/4885HPGD 2893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.