SCHEMBL8154040

SCHEMBL8154040

OC(C(Cl)(Cl)Cl)P(O)(O)=S

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.39
CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8160584 1.00 LMNA (0.39) LMNACYP2C19
SCHEMBL8155311 1.00 LMNA (0.39) LMNACYP2C19
SCHEMBL8155737 0.69 KDM4E (0.31)
SCHEMBL11411465 0.69 LMNA (0.50) LMNACYP2C19
SCHEMBL8154976 0.69 KDM4E (0.31)
SCHEMBL3244386 0.69 LMNA (0.56) LMNACYP2C19
SCHEMBL8154487 0.69 KDM4E (0.31)
SCHEMBL28351185 0.67 LMNA (0.54) LMNACYP2C19
SCHEMBL10021627 0.67 LMNA (0.54) LMNACYP2C19
Chloral Hydrate SCHEMBL34327 0.58

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2000510455-A 2000-08-15 JP claimed
EP-0896540-A1 USE OF PHOSPHONIC ACID ESTERS FOR THE TREATMENT OF FUNCTIONAL DISORDERS OF THE BRAIN AND DEPRESSION Troponwerke GmbH & Co. KG (DE) 1999-02-17 EP claimed
WO-1997039756-A1 USE OF PHOSPHONIC ACID ESTERS FOR THE TREATMENT OF FUNCTIONAL DISORDERS OF THE BRAIN AND DEPRESSION TROPONWERKE GMBH & CO. KG (DE) 1997-10-30 WO claimed
EP-0896540-A1 USE OF PHOSPHONIC ACID ESTERS FOR THE TREATMENT OF FUNCTIONAL DISORDERS OF THE BRAIN AND DEPRESSION Troponwerke GmbH & Co. KG (DE) 1999-02-17 EP disclosed
WO-1997039756-A1 USE OF PHOSPHONIC ACID ESTERS FOR THE TREATMENT OF FUNCTIONAL DISORDERS OF THE BRAIN AND DEPRESSION TROPONWERKE GMBH & CO. KG (DE) 1997-10-30 WO disclosed
US-4335117-A 1-Hydroxy-2,2,2-trichloroethane-thionophosphonic acid dimethyl esters as insecticide BAYER AKTIENGESELLSCHAFT (DE) 1982-06-15 US disclosed
US-4335117-A 1-Hydroxy-2,2,2-trichloroethane-thionophosphonic acid dimethyl esters as insecticide BAYER AKTIENGESELLSCHAFT (DE) 1982-06-15 US disclosed