Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.76 |
| ▸ | TSHR | P16473 | 3/20 | 0.75 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579131 | 0.91 | SLC6A7 (0.83) | SLC6A7ALDH1A1MAPK1L3MBTL1KDM4E | |
| SCHEMBL3580034 | 0.91 | KDM4E (0.92) | SLC6A7ALDH1A1MAPK1L3MBTL1KDM4E | |
| SCHEMBL13601160 | 0.88 | ALDH1A1 (0.79) | SLC6A7ALDH1A1MAPK1L3MBTL1KDM4E | |
| SCHEMBL3578857 | 0.88 | SLC6A7 (0.78) | SLC6A7ALDH1A1MAPK1L3MBTL1KDM4E | |
| SCHEMBL3582024 | 0.87 | SLC6A7 (0.77) | SLC6A7ALDH1A1MAPK1L3MBTL1KDM4E | |
| SCHEMBL3582926 | 0.87 | SLC6A7 (0.77) | SLC6A7ALDH1A1MAPK1L3MBTL1KDM4E | |
| SCHEMBL34468359 | 0.87 | ALDH1A1 (0.78) | SLC6A7ALDH1A1MAPK1L3MBTL1KDM4E | |
| SCHEMBL15703668 | 0.86 | ALDH1A1 (0.76) | SLC6A7ALDH1A1MAPK1L3MBTL1KDM4E | |
| SCHEMBL95027 | 0.86 | ALDH1A1 (0.76) | SLC6A7ALDH1A1MAPK1L3MBTL1KDM4E | |
| SCHEMBL12082726 | 0.86 | KDM4E (1.00) | SLC6A7ALDH1A1MAPK1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042855-A1 | BENZAMIDE mGluR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | DEPARTMENT OF VETERANS AFFAIRS | 2009-02-12 | — | — | US | disclosed |
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042855-A1 | BENZAMIDE mGluR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM3 | SLC6A7 633/4885ALDH1A1 4092/4885MAPK1 2368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.