Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.32 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 2/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608252 | 0.82 | CRHBP (0.42) | ABCB1ABCC1CRHBPCRHR2 | |
| SCHEMBL30145522 | 0.70 | CRHBP (0.53) | ABCB1ABCC1CYP11B1CYP11B2CRHBP | |
| SCHEMBL14928247 | 0.70 | CRHBP (0.53) | ABCB1ABCC1CYP11B1CYP11B2CRHBP | |
| SCHEMBL4609299 | 0.67 | MAPT (0.48) | CRHBPCRHR2 | |
| SCHEMBL4608316 | 0.66 | ABCB1 (0.44) | ABCB1ABCC1 | |
| SCHEMBL8365480 | 0.62 | ABCB1 (0.49) | ABCB1ABCC1CRHBPCRHR2 | |
| SCHEMBL16997449 | 0.61 | TDP1 (0.50) | ABCB1ABCC1CYP11B1CYP11B2CRHBP | |
| SCHEMBL2601600 | 0.61 | CRHBP (0.58) | ABCB1ABCC1CRHBPCRHR2 | |
| SCHEMBL9197991 | 0.61 | AAK1 (0.60) | — | |
| SCHEMBL14928233 | 0.61 | MEN1 (0.51) | ABCB1ABCC1CYP11B1CYP11B2CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1059927-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | AstraZeneca AB (SE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999044618-A1 | CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | disclosed |