Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HMGCR | P04035 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | RARB | P10826 | 3/20 | 0.43 |
| ▸ | RARA | P10276 | 2/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29460666 | 0.81 | MAPT (0.56) | PTPN1PTPN11LMNAMAPTXBP1 | |
| SCHEMBL15524242 | 0.81 | MAPT (0.56) | PTPN1PTPN11LMNAMAPTXBP1 | |
| SCHEMBL8466537 | 0.81 | PTPN1 (0.40) | PTPN1PTPN11LMNAMAPTXBP1 | |
| SCHEMBL15524861 | 0.79 | PTPN1 (0.53) | PTPN1PTPN11LMNAMAPTXBP1 | |
| SCHEMBL6551567 | 0.78 | RARB (0.38) | PTPN1PTPN11LMNARARBRARA | |
| SCHEMBL16736769 | 0.77 | HMGCR (0.50) | PTPN1PTPN11LMNAMAPTXBP1 | |
| SCHEMBL15462898 | 0.77 | GABRP (0.42) | LMNARARBRARARARGTSHR | |
| SCHEMBL16736920 | 0.77 | HMGCR (0.53) | PTPN1PTPN11LMNAMAPTXBP1 | |
| SCHEMBL22222257 | 0.76 | KDM4E (0.47) | PTPN1LMNAMAPTHIF1AALDH1A1 | |
| SCHEMBL30892458 | 0.76 | KDM4E (0.47) | PTPN1LMNAMAPTHIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686145-B1 | NEW COMPOUNDS | UNIV MARYLAND (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5883129-A | Hydroxylated anthranilic acid derivatives | ASTRA AKTIEBOLAG (SE) | 1999-03-16 | — | — | US | disclosed |
| US-5523475-A | New compounds | AKTIEBOLAGET ASTRA (SE) | 1996-06-04 | — | — | US | disclosed |
| CN-1121345-A | New compounds | ASTRA AB (SE) | 1996-04-24 | — | — | CN | disclosed |
| EP-0686145-A1 | NEW COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019316-A1 | NEW COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1994-09-01 | — | — | WO | disclosed |