Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8161960 | 0.96 | GRM5 (0.47) | GRM5MMP2MMP9LMNAMMP12 | |
| SCHEMBL3643275 | 0.84 | GRM5 (0.69) | GRM5EPHX1MEN1LMNARAB9A | |
| SCHEMBL8163323 | 0.82 | GRM5 (0.69) | GRM5MMP2MMP9KDM4EMEN1 | |
| SCHEMBL8168370 | 0.81 | GRM5 (0.45) | GRM5MMP2MMP9EPHX1KDM4E | |
| SCHEMBL3641476 | 0.81 | GRM5 (0.67) | GRM5EPHX1KDM4EMEN1LMNA | |
| SCHEMBL8154357 | 0.80 | L3MBTL3 (0.52) | GRM5 | |
| SCHEMBL8160754 | 0.80 | L3MBTL3 (0.49) | GRM5 | |
| SCHEMBL8161856 | 0.78 | GRM5 (0.50) | GRM5MMP2MMP9MMP12 | |
| SCHEMBL8162167 | 0.77 | GRM5 (0.44) | GRM5MMP2MMP9NPC1RAB9A | |
| SCHEMBL8159305 | 0.76 | GRM5 (0.48) | GRM5MMP2MMP9KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |