Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM3 | Q14832 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 11/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8166489 | 0.87 | GRM3 (0.51) | GRM3GRM5 | |
| SCHEMBL8161987 | 0.86 | GRM3 (0.46) | GRM3GRM5 | |
| SCHEMBL8160780 | 0.86 | GRM3 (0.46) | GRM3GRM5 | |
| SCHEMBL8155708 | 0.85 | GRM5 (0.44) | GRM3GRM5CYP26A1CYP3A4RARA | |
| SCHEMBL8168267 | 0.85 | OPRM1 (0.46) | GRM3GRM5RARARARBRARG | |
| SCHEMBL8166622 | 0.84 | CA12 (0.45) | GRM5LMNAALDH1A1POLB | |
| SCHEMBL3638549 | 0.83 | GRM3 (0.74) | GRM3GRM5LMNAHTTMEN1 | |
| SCHEMBL8159187 | 0.83 | GRM5 (0.41) | GRM3GRM5LMNAHTTALDH1A1 | |
| SCHEMBL8155823 | 0.83 | GRM3 (0.47) | GRM3GRM5CYP26A1CYP3A4RARA | |
| SCHEMBL8162119 | 0.81 | GRM5 (0.68) | GRM5ALDH1A1POLBMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |