Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.44 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RARA | P10276 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | MMP15 | P51511 | 1/20 | 0.35 |
| ▸ | MMP16 | P51512 | 1/20 | 0.35 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154259 | 0.85 | GRM3 (0.52) | GRM5GRM3CYP26A1CYP3A4RARA | |
| SCHEMBL8164563 | 0.82 | GRM5 (0.40) | GRM5MMP2MMP9MMP12MMP14 | |
| SCHEMBL3640039 | 0.82 | GRM5 (0.62) | GRM5GRM3 | |
| SCHEMBL8162119 | 0.77 | GRM5 (0.68) | GRM5 | |
| SCHEMBL8168267 | 0.76 | OPRM1 (0.46) | GRM5GRM3RARARARBRARG | |
| SCHEMBL8166622 | 0.75 | CA12 (0.45) | GRM5 | |
| SCHEMBL8166450 | 0.75 | GRM5 (0.52) | GRM5GRM3APPMMP2MMP9 | |
| SCHEMBL8171419 | 0.74 | GRM5 (0.41) | GRM5GRM3 | |
| SCHEMBL8160754 | 0.74 | L3MBTL3 (0.49) | GRM5 | |
| SCHEMBL8154357 | 0.74 | L3MBTL3 (0.52) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |