Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL123930 | 0.96 | ALDH1A1 (0.57) | ALDH1A1HPGDAKR1C3USP2LMNA | |
| SCHEMBL8330770 | 0.92 | ALDH1A1 (0.50) | ALDH1A1HPGDAKR1C3USP2LMNA | |
| SCHEMBL1696787 | 0.82 | USP2 (0.55) | ALDH1A1HPGDAKR1C3USP2LMNA | |
| SCHEMBL21770514 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HPGDAKR1C3USP2LMNA | |
| SCHEMBL8149641 | 0.82 | ALDH1A1 (0.57) | ALDH1A1HPGDAKR1C3USP2LMNA | |
| SCHEMBL79080 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HPGDAKR1C3USP2LMNA | |
| SCHEMBL10112811 | 0.81 | IDO1 (0.57) | ALDH1A1HPGDAKR1C3USP2TSHR | |
| SCHEMBL11142367 | 0.80 | ALDH1A1 (0.74) | ALDH1A1HPGDAKR1C3TSHRSMN1; SMN2 | |
| SCHEMBL6330306 | 0.80 | IDO1 (0.56) | ALDH1A1HPGDAKR1C3MAPTTSHR | |
| SCHEMBL85175 | 0.79 | ALDH1A1 (0.58) | ALDH1A1HPGDAKR1C3USP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6077853-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 2000-06-20 | — | — | US | disclosed |
| US-5939439-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-08-17 | — | — | US | disclosed |