Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | HIPK1 | Q86Z02 | 2/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.64 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.61 |
| ▸ | CDK9 | P50750 | 5/20 | 0.61 |
| ▸ | PRKCB | P05771 | 3/20 | 0.61 |
| ▸ | PRKCA | P17252 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5583029 | 0.95 | MEN1 (0.72) | MEN1TP53CYP3A4MAPTALOX15 | |
| SCHEMBL8166773 | 0.94 | MEN1 (0.68) | MEN1TP53CYP3A4MAPTALOX15 | |
| SCHEMBL8161679 | 0.93 | MEN1 (0.67) | MEN1TP53CYP3A4MAPTALOX15 | |
| SCHEMBL8154377 | 0.83 | MEN1 (0.89) | MEN1TP53CYP3A4MAPTALOX15 | |
| SCHEMBL8160687 | 0.82 | MEN1 (0.56) | MEN1TP53CYP3A4MAPTALOX15 | |
| Bisindolylmaleimide Ix SCHEMBL2491726 | 0.78 | MEN1 (1.00) | MEN1TP53CYP3A4MAPTALOX15 | |
| Bisindolylmaleimide Ix SCHEMBL29381390 | 0.78 | MEN1 (1.00) | MEN1TP53CYP3A4MAPTALOX15 | |
| SCHEMBL8166772 | 0.77 | MEN1 (0.95) | MEN1TP53CYP3A4MAPTALOX15 | |
| SCHEMBL8161675 | 0.76 | MEN1 (0.93) | MEN1TP53CYP3A4MAPTALOX15 | |
| Bisindolylmaleimide Ix SCHEMBL29370657 | 0.76 | PRKCA (1.00) | MEN1TP53CYP3A4MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36736-E | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 2000-06-13 | — | — | US | disclosed |
| US-5057614-A | Antiinflammatory, immunology, bronchodilator agents, cardiovascular disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-10-15 | — | — | US | disclosed |