Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025724 | 0.89 | NPSR1 (0.50) | MEN1KMT2ANPC1LMNANPSR1 | |
| SCHEMBL9025718 | 0.89 | NPSR1 (0.50) | MEN1KMT2ANPC1LMNANPSR1 | |
| SCHEMBL9025739 | 0.89 | NPSR1 (0.50) | MEN1KMT2ANPC1LMNANPSR1 | |
| SCHEMBL9026079 | 0.88 | ALDH1A1 (0.48) | MEN1KMT2AHTTNPC1LMNA | |
| SCHEMBL9026073 | 0.88 | ALDH1A1 (0.48) | MEN1KMT2AHTTNPC1LMNA | |
| SCHEMBL9026068 | 0.88 | ALDH1A1 (0.48) | MEN1KMT2AHTTNPC1LMNA | |
| SCHEMBL8125588 | 0.87 | RIPK1 (0.52) | MEN1KMT2ANPC1RIPK1LMNA | |
| SCHEMBL9024840 | 0.87 | RIPK1 (0.52) | MEN1KMT2ANPC1RIPK1LMNA | |
| SCHEMBL5784217 | 0.87 | RIPK1 (0.52) | MEN1KMT2ANPC1RIPK1LMNA | |
| SCHEMBL9025059 | 0.87 | RIPK1 (0.52) | MEN1KMT2ANPC1RIPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071927-A | Spiro-piperidine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2000-06-06 | — | — | US | disclosed |
| EP-0683767-B1 | AZACYCLIC COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME (GB) | 1998-06-03 | — | — | EP | disclosed |
| US-5633266-A | Azacyclic compounds compositions containing them and their use as tachykinin antagonists | MERCK SHARP & DOHME LTD. (GB) | 1997-05-27 | — | — | US | disclosed |