Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | BPTF | Q12830 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLA1 | P09884 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7253779 | 0.76 | — | — | |
| SCHEMBL7259083 | 0.74 | — | — | |
| SCHEMBL8154422 | 0.74 | — | — | |
| SCHEMBL5940600 | 0.74 | — | — | |
| SCHEMBL8154174 | 0.73 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2ATP53USP2 | |
| SCHEMBL24469576 | 0.71 | CYP3A4 (0.64) | ALDH1A1CYP3A4CYP1A2POLBCYP2C19 | |
| SCHEMBL29666975 | 0.71 | CYP3A4 (0.64) | ALDH1A1CYP3A4CYP1A2POLBCYP2C19 | |
| SCHEMBL24469575 | 0.71 | CYP3A4 (0.64) | ALDH1A1CYP3A4CYP1A2POLBCYP2C19 | |
| SCHEMBL6780106 | 0.71 | — | — | |
| SCHEMBL8152565 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772439-B1 | Novel antibiotic compounds and antibiotic compositions comprising said compounds for inhibiting gram positive bacteria and mycoplasma cells. | UNIV MASSACHUSETTS MEDICAL (US) | 2000-10-04 | — | — | EP | claimed |
| EP-0772439-A4 | NOVEL ANTIBIOTIC COMPOUNDS AND METHODS TO TREAT GRAM-POSITIVE BACTERIAL AND MYCOPLASMAL INFECTIONS | UNIV MASSACHUSETTS MEDICAL (US) | 1998-01-07 | — | — | EP | claimed |
| EP-0772439-A1 | NOVEL ANTIBIOTIC COMPOUNDS AND METHODS TO TREAT GRAM-POSITIVE BACTERIAL AND MYCOPLASMAL INFECTIONS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1997-05-14 | — | — | EP | claimed |
| US-5516905-A | ENZYME INHIBITORS OF DNA POLYMERASE FOR BACTERICIDES | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1996-05-14 | — | — | US | claimed |
| WO-1996006614-A1 | NOVEL ANTIBIOTIC COMPOUNDS AND METHODS TO TREAT GRAM-POSITIVE BACTERIAL AND MYCOPLASMAL INFECTIONS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1996-03-07 | — | — | WO | claimed |
| EP-0772439-B1 | Novel antibiotic compounds and antibiotic compositions comprising said compounds for inhibiting gram positive bacteria and mycoplasma cells. | UNIV MASSACHUSETTS MEDICAL (US) | 2000-10-04 | — | — | EP | disclosed |
| EP-0772439-A4 | NOVEL ANTIBIOTIC COMPOUNDS AND METHODS TO TREAT GRAM-POSITIVE BACTERIAL AND MYCOPLASMAL INFECTIONS | UNIV MASSACHUSETTS MEDICAL (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0772439-A1 | NOVEL ANTIBIOTIC COMPOUNDS AND METHODS TO TREAT GRAM-POSITIVE BACTERIAL AND MYCOPLASMAL INFECTIONS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5516905-A | ENZYME INHIBITORS OF DNA POLYMERASE FOR BACTERICIDES | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1996-05-14 | — | — | US | disclosed |
| WO-1996006614-A1 | NOVEL ANTIBIOTIC COMPOUNDS AND METHODS TO TREAT GRAM-POSITIVE BACTERIAL AND MYCOPLASMAL INFECTIONS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1996-03-07 | — | — | WO | disclosed |