SCHEMBL8154902

SCHEMBL8154902

CCCCCCCCCCc1ccc(-c2ncc(OS(=O)(=O)C(F)(F)F)cn2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.56
RAB9A P51151 3/20 0.56
MEN1 O00255 2/20 0.56
ALDH1A1 P00352 2/20 0.56
KMT2A Q03164 2/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
KDM4E B2RXH2 1/20 0.56
USP2 O75604 1/20 0.56
GAA P10253 1/20 0.56
HPGD P15428 1/20 0.56
HSD17B10 Q99714 1/20 0.56
RARB P10826 9/20 0.53
RARA P10276 2/20 0.46
MTOR P42345 1/20 0.46
NPC1 O15118 1/20 0.43
NFKB1 P19838 1/20 0.43
NFKB2 Q00653 1/20 0.43
RELA Q04206 1/20 0.43
S1PR4 O95977 1/20 0.42
S1PR1 P21453 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6018128 0.99 MAPT (0.55) MAPTRAB9AMEN1ALDH1A1KMT2A
SCHEMBL8552231 0.84 RARB (0.52) MAPTMEN1ALDH1A1KMT2AHSD17B10
SCHEMBL7104301 0.84 NPC1 (0.50) MAPTRAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL7105435 0.84 NPC1 (0.50) MAPTRAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL7930478 0.81 CA2 (0.50) ALDH1A1SMN1; SMN2KDM4EHSD17B10RARB
SCHEMBL22666338 0.80 CA2 (0.49) ALDH1A1SMN1; SMN2KDM4EHSD17B10RARB
SCHEMBL9636329 0.79 RAB9A (0.68) MAPTRAB9AMEN1ALDH1A1KMT2A
SCHEMBL10469637 0.79 RAB9A (0.68) MAPTRAB9AMEN1ALDH1A1KMT2A
SCHEMBL9635847 0.79 RAB9A (0.68) MAPTRAB9AMEN1ALDH1A1KMT2A
SCHEMBL10469584 0.79 RAB9A (0.68) MAPTRAB9AMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0666262-B1 Optically active compound, liquid crystal containing the same, liquid crystal device and display method using the same CANON KK (JP) 2000-08-30 EP disclosed
US-5849217-A Optically active compound, liquid crystal composition containing the same, liquid crystal device using the same, liquid crystal apparatus and display method CANON KABUSHIKI KAISHA (JP) 1998-12-15 US disclosed
EP-0666262-A1 Optically active compound, liquid crystal containing the same, liquid crystal device and display method using the same CANON KABUSHIKI KAISHA (JP) 1995-08-09 EP disclosed