Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8135393 | 0.91 | EPHX2 (0.59) | EPHX2CA12CA1CA2CA9 | |
| SCHEMBL8118160 | 0.91 | KMT2A (0.56) | EPHX2MAPTCA12CA1CA2 | |
| SCHEMBL6295057 | 0.87 | DDR1 (0.59) | MAPTDDR1DDR2NTRK1NTRK3 | |
| SCHEMBL8118038 | 0.86 | CHRNA7 (0.49) | EPHX2MAPTNPC1RAB9APOLB | |
| SCHEMBL8131703 | 0.82 | RAB9A (0.66) | EPHX2MAPTCA12CA1CA2 | |
| SCHEMBL8155988 | 0.82 | RAF1 (0.49) | EPHX2MAPTNPC1RAB9AROCK2 | |
| SCHEMBL8116428 | 0.81 | LMNA (0.53) | EPHX2MAPTNPC1RAB9AROCK2 | |
| SCHEMBL8118107 | 0.81 | EPHX2 (0.61) | EPHX2MAPTNPC1RAB9APOLB | |
| SCHEMBL8130701 | 0.81 | NPC1 (0.65) | MAPTNPC1RAB9AROCK2POLB | |
| SCHEMBL6293966 | 0.81 | DDR1 (0.56) | DDR1DDR2NTRK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005459-A1 | SUBSTITUTED ISOQUINOLINES AS ANTICONVULSIVANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999014197-A1 | SUBSTITUTED ISOQUINOLINES AS ANTICONVULSIVANTS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-25 | — | — | WO | disclosed |