Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.54 |
| ▸ | DRD3 | P35462 | 6/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7245474 | 1.00 | DRD2 (0.54) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL6817140 | 1.00 | DRD2 (0.54) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL4222382 | 0.96 | DRD2 (0.54) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL7239637 | 0.88 | DRD2 (0.42) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL7239524 | 0.86 | DRD2 (0.43) | DRD2DRD3 | |
| SCHEMBL7240500 | 0.85 | DRD2 (0.43) | DRD2DRD3 | |
| SCHEMBL7244550 | 0.85 | DRD2 (0.46) | DRD2DRD3DRD4 | |
| SCHEMBL6819394 | 0.85 | DRD2 (0.43) | DRD2DRD3 | |
| SCHEMBL6816670 | 0.83 | DRD2 (0.48) | DRD2DRD3 | |
| SCHEMBL8157601 | 0.83 | DRD2 (0.48) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014985-A1 | A COMBINATION OF A 5-HT REUPTAKE INHIBITOR AND A h5-HT 1B ANTAGONIST OR PARTIAL AGONIST | AstraZeneca AB (SE) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999013877-A1 | A COMBINATION OF A 5-HT REUPTAKE INHIBITOR AND A h5-HT1B ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 1999-03-25 | — | — | WO | disclosed |