Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 10/20 | 1.00 |
| ▸ | PARP11 | Q9NR21 | 10/20 | 1.00 |
| ▸ | GRM5 | P41594 | 4/20 | 0.65 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.61 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.61 |
| ▸ | PARP1 | P09874 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16561672 | 0.86 | PARP10 (0.76) | PARP10PARP11GRM5CLK4PARP1 | |
| SCHEMBL13680532 | 0.85 | CLK4 (0.78) | PARP10PARP11GRM5FYNCLK4 | |
| SCHEMBL8155722 | 0.84 | PARP11 (1.00) | PARP10PARP11GRM5CLK4DYRK1B | |
| SCHEMBL279903 | 0.82 | PARP10 (1.00) | PARP10PARP11GRM5PARP1PDPK1 | |
| SCHEMBL29978302 | 0.82 | PARP10 (1.00) | PARP10PARP11GRM5PARP1PDPK1 | |
| SCHEMBL8159245 | 0.82 | PARP10 (1.00) | PARP10PARP11GRM5PARP1PDPK1 | |
| SCHEMBL8154135 | 0.82 | PARP10 (0.69) | PARP10PARP11GRM5PARP1PDPK1 | |
| SCHEMBL20294385 | 0.82 | PARP11 (0.72) | PARP10PARP11GRM5PARP1PDPK1 | |
| SCHEMBL8154134 | 0.79 | PARP11 (0.68) | PARP10PARP11GRM5PARP1PDPK1 | |
| SCHEMBL23657097 | 0.79 | PARP10 (0.65) | PARP10PARP11GRM5PARP1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |